I drove my X across the country and can attest to it being very capable on road. It is a comfortable ride, not a lot of road noise, plenty of space for hauling my stuff, and has a great sounds system with the iPod connection.
I was in the car about 12-13 hours a day and was only mentally tired, not physically tired from driving. I can't say that for the Jeep I used to own back in college where it felt like I was in a fight after 3-4 hours on the road. Not really a surprise, but the only drawback I had was encountering high winds which tend to blow the truck around. As long as you expect to have that it is no big deal.